Drug-induced arrhythmia: pharmacogenomic prescribing?
نویسندگان
چکیده
منابع مشابه
Drug-induced arrhythmia: pharmacogenomic prescribing?
Drug-induced Torsades de Pointes is a rare, unpredictable, and life-threatening serious adverse event. It can be caused by both cardiac and non-cardiac drugs and has become a major issue in novel drug development and for the regulatory authorities. This review describes the problem, predisposing factors, and the underlying genetic predisposition as it is understood currently. The future potenti...
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Prolongation of the QTc interval has been associated with proarrhythmia resulting from a potentially fatal form of polymorphic ventricular tachycardia called torsades de pointes (TdP). Genetic forms of the long-QT syndrome (LQTS) associated with high arrhythmic risk have been causally related to mutations in ion channels responsible for the cardiac action potential; genetic factors associated w...
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BACKGROUND Medical specialists are often seen as the first prescribers of new drugs. However, the extent to which specialists influence new drug prescribing in primary care is largely unknown. METHODS This study estimates the influence of medical specialists on new drug prescribing in primary care shortly after market introduction. The influence of medical specialists on prescribing of five n...
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Since the introduction of our local manufacturing of terfenadine, we have observed and expressed our concern about a small but increasing number of serious ventricular arrhythmias associated with the use of this non sedating antihistamine. In January 1997 a case of torsade de pointes ventricular tachycardia was detected in a previously healthy woman taking terfenadine with erythromycin. El...
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Tingyu Gong, Arun Sharma, Paul W. Burridge, Bhagat Patlolla, Andrew S. Lee, Haodi Wu, Enrique G. Navarrete, Ping Liang, Feng Lan, Verónica Sanchez-Freire, Chelsey Simmons, Derived Cardiomyocytes and Low-Impedance Microelectrode Arrays − Screening Drug-Induced Arrhythmia Events Using Human Induced Pluripotent Stem Cell Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2013 American Heart...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2012
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/ehs351